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Immunoreceptor tyrosine-based activation motif
・ Immunoreceptor tyrosine-based inhibitory motif
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Immunoreceptor tyrosine-based activation motif : ウィキペディア英語版
Immunoreceptor tyrosine-based activation motif
An immunoreceptor tyrosine-based activation motif (ITAM) (in the antagonistic case ITIM, I for inhibition) is a conserved sequence of four amino acids that is repeated twice in the cytoplasmic tails of certain cell surface proteins of the immune system.
==Structure==
The motif contains a tyrosine separated from a leucine or isoleucine by any two other amino acids, giving the signature YxxL/I.〔 Two of these signatures are typically separated by between 6 and 8 amino acids in the tail of the molecule (YxxL/Ix(6-8)YxxL/I).

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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